First, wet granulation machine is how it works: wet granulation technique in the preparation of traditional Chinese medicine tablets in the 1950s, when most used granules. Compared with the requirement to carry out preparations now, the traditional wet granulation technique there is a significant deficiency. Mainly as follows: The accessories used often restricted to powdered sugar, starch, dextrin. During significantly hygroscopic powdered sugar; starch with acid, base, or in a wet and heated state will gradually lose swell effect hydrolysis; because dextrin determination of the content of certain drugs have disturbed, it is sometimes not as filler; traditional technologies often to extract ratio, extract empirical determination and consistency to determine the amount of materials, affecting the quality of preparation handling norms; hygroscopic drugs and excipients, if the particles prepared by wet granulation technique, particles are kneaded together, showing adhesion, a strip of soft material, sticky nets and so on, prepared and poorly soluble particles excellent quality of instability. Second, after the development of efficient wet granulation machine: domestic research personnel selection orthogonal experiment method hypoglycemic granules (sugar-free granules) by the use of soluble starch as excipients, sweet vegetarian as flavoring agent technology the discussion. Achievements OK to Medical Herbs cream: soluble starch: sweet vegetarian ratio of 1:2:0.025 plan for the best technical parameters granulation. With a single factor and orthogonal to pick prescription technology ShengmaiYin particles, the results showed that the diluent is lactose - microcrystalline cellulose - trisilicate (12:5:3), adhesives 5% povidone ketone (PVP) solution, mixing time is preferably 150 seconds. Together with moisture percentage target, the selection of different materials, and to further assess its liquidity and critical relative humidity. Determine the outcome: the choice of materials made of particles of microcrystalline cellulose, not only to improve the preparation of stability and mobility, but also improve the dissolution rate of the capsule. 

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